Chlamydiae growing in target mucosal human epithelial cells in vitro can transition from their
normal developmental cycle progression, alternating between infectious but metabolically …

The chlamydiae are an evolutionarily distinct group of eubacteria sharing an obligate
intracellular lifestyle and a unique developmental cycle that has been well characterized …

Chlamydial persistence is a reversible state generated during conditions deleterious to
growth. In persistence, Chlamydia trachomatis remains viable but atypical, with an enlarged …

Chlamydiae are medically important bacteria responsible for a wide range of human
infections and diseases. Repeated episodes of infection promote chronic inflammation …

Gamma interferon induces persistent chlamydial infections in cell culture. These infections
are characterized by altered morphologic and biochemical features of the pathogen. These …

T he chlamydiae are among the most common human pathogens and are an extremely
important public health problem worldwide, both medically and economically (Table 1) …

The ability to cause persistent infection is one of the major characteristics of all chlamydial
species in their appropriate hosts. Persistent infection with Chlamydia trachomatis and …

Background Despite small genomic differences, Chlamydia trachomatis biovars exhibit
diverse disease manifestations and different growth rates in vivo and in cell culture models …

Chlamydia trachomatis is among the most clinically significant human pathogens, yet their
obligate intracellular nature places severe restrictions upon research. Chlamydiae undergo …

Under stress, chlamydiae can enter a non-infectious but viable state termed persistence. In
the absence of a tractable genetic system, persistence induction provides an important …