Primary biliary cholangitis: pathophysiology

I Houri, GM Hirschfield - Clinics in Liver Disease, 2024 - liver.theclinics.com
Primary biliary cholangitis (PBC) is the most common of the autoimmune liver diseases, with
a female predominance and prevalence that varies greatly geographically with reports of 19 …

Prediction and evaluation of high-risk patients with primary biliary cholangitis receiving ursodeoxycholic acid therapy: an early criterion

C Yang, G Guo, B Li, L Zheng, R Sun, X Wang… - Hepatology …, 2023 - Springer
Background and aims Current treatment guidelines recommend ursodeoxycholic acid
(UDCA) as the first-line treatment for new-diagnosed primary biliary cholangitis (PBC) …

Primary biliary cholangitis drug evaluation and regulatory approval: Where do we go from here?

DEJ Jones, U Beuers, A Bonder, M Carbone… - Hepatology, 2024 - journals.lww.com
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease. The management
landscape was transformed 20 years ago with the advent of ursodeoxycholic acid. Up to …

Natural history of primary biliary cholangitis in the ursodeoxycholic acid era: role of scoring systems

A Goel, WR Kim - Clinics in Liver Disease, 2018 - liver.theclinics.com
Primary biliary cholangitis (PBC), previously referred to as primary biliary cirrhosis, is a
progressive cholestatic liver disease characterized by the destruction of small intrahepatic …

A comparison of prognostic scores (Mayo, UK-PBC, and GLOBE) in primary biliary cholangitis

JC Goet, CFM Perez, MH Harms… - Official journal of the …, 2021 - journals.lww.com
METHODS: Ursodeoxycholic acid–treated patients from 7 centers participating in the
GLOBAL PBC Study Group were included. The discriminatory performance of the scores …

Primary biliary cholangitis: pathogenesis and therapeutic opportunities

AF Gulamhusein, GM Hirschfield - Nature Reviews Gastroenterology & …, 2020 - nature.com
Primary biliary cholangitis is a chronic, seropositive and female-predominant inflammatory
and cholestatic liver disease, which has a variable rate of progression towards biliary …

[HTML][HTML] Clinical features and treatment outcomes of primary biliary cholangitis in a highly admixed population

GGL Cançado, MH Braga, MLG Ferraz… - Annals of hepatology, 2022 - Elsevier
Introduction and objectives Little is known about primary biliary cholangitis (PBC) in non-
whites. The purpose of this study was to evaluate clinical features and outcomes of PBC in a …

Primary biliary cholangitis in Spain. Results of a Delphi study of epidemiology, diagnosis, follow-up and treatment

A Parés, A Albillos, RJ Andrade, M Berenguer… - Revista Española de …, 2018 - idus.us.es
Introduction: primary biliary cholangitis (PBC) is a rare disease with limited data regarding its
epidemiology and standard clinical management in Spain. Objective: to gain insight into the …

Changes in the epidemiology of primary biliary cholangitis

A Lleo, F Colapietro - Clinics in liver disease, 2018 - liver.theclinics.com
Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, 1 is an
autoimmune liver disease characterized by circulating anti-mitochondrial antibodies (AMA) …

Geoepidemiology and changing mortality in primary biliary cholangitis

A Floreani, A Tanaka, C Bowlus… - Journal of gastroenterology, 2017 - Springer
Primary biliary cholangitis (PBC), formerly called primary biliary cirrhosis, is a chronic
cholestatic disease characterized by an autoimmune-mediated destruction of small and …