Acute and chronic inflammation play a central role in the pathophysiology of atherosclerosis.
Corticosteroids are the gold standard anti-inflammatory agent and may have a role in …

INTRODUCTION: A few epidemiological studies suggested an increased coronary heart
disease (CHD) risk with high doses of oral corticosteroids. METHODS: We performed a …

Background: Mineralocorticoid receptor antagonists (MRA) improve outcome in the setting of
post–myocardial infarction (MI) heart failure (HF). Objectives: The study sought to assess the …

Objective To assess the effects of corticosteroids on mortality in patients with severe sepsis
and septic shock. Data sources Randomised and quasi-randomised trials of corticosteroids …

Background: Previous meta-analyses demonstrated that high-dose glucocorticoids were not
beneficial in sepsis. Recently, lower-dose glucocorticoids have been studied. Purpose: To …

Abstract creatine kinase methylprednisolone clinical study drug blood level drug therapy
heart infarction heart ventricle arrhythmia intravenous drug administration major clinical …

BACKGROUND: Randomized trials investigating the effect of corticosteroids in the treatment
of acute lung injury, acute respiratory distress syndrome, and severe pneumonia have had …

Context The benefit of corticosteroids in severe sepsis and septic shock remains
controversial. Objective We examined the benefits and risks of corticosteroid treatment in …

Introduction Glucocorticosteroids (steroids) are widely used for sepsis patients. However, the
potential benefits and harms of both high and low dose steroids remain unclear. A …

Do corticosteroids reduce death or improve recovery in people with sepsis or septic shock?
Our panel make a weak recommendation to give corticosteroids to people with all types and …