Cancer pain significantly affects the diagnosis, quality of life and survival of patients with
cancer. During the past decade, preclinical and clinical data has begun to provide insight …

Cancer colonization of bone leads to the activation of osteoclasts, thereby producing local
tissue acidosis and bone resorption. This process may contribute to the generation of both …

In an experimental model of cancer pain, the hyperalgesia that occurs with osteolytic tumor
growth is associated with the sensitization of nociceptors. We examined functional and …

Pain associated with bone cancer remains poorly managed, and chemotherapeutic drugs
used to treat cancer usually increase pain. The discovery of dual-acting drugs that reduce …

Cancer pain is a debilitating disorder and a primary determinant of the poor quality of life.
Here, we report a non-vascular role for ligands of the Vascular Endothelial Growth Factor …

Objective In this review, we explain our current understanding of the molecular basis for pain
relief by capsaicin and other transient receptor potential vanilloid subfamily, member 1 …

In many patients with cancer, chemotherapy-induced severe oral ulcerative mucositis
causes intractable pain, leading to delays and interruptions in therapy. However, the pain …

Sensory nerves sensitive to capsaicin are afferent nerve fibers which contain TRPV1
channels. Activation of these channels induces release of neuropeptides which regulate …

Cancer-associated pain can be present at any time during the course of the disease, but the
frequency and intensity of cancer pain tends to increase with advancing stages of cancer. In …

Cancer pain, especially pain caused by metastasis to bone, is a severe type of pain, and
unless the cause and consequences can be resolved, the pain will become chronic. As …