BACKGROUND: Pain is one of the first presenting symptoms in patients with head and neck
cancer, who often develop chronic and debilitating pain as the disease progresses. Pain is …

Inflammation is one of the most important causes of the majority of cancer symptoms,
including pain, fatigue, cachexia, and anorexia. Cancer pain affects 17 million people …

Background In a previous study, persistent pain was suggested to be a risk factor for tumor
patients. However, the mechanism underlying this phenomenon is still unclear. Substance P …

Recently programmed death-ligand 1 (PD-L1) receptor PD-1 was found in dorsal root
ganglion (DRG) neurons, and PD-L1 activates PD-1 to inhibit inflammatory and neuropathic …

Patients with oral cancer report severe pain during function. Inflammation plays a role in the
oral cancer microenvironment; however, the role of immune cells and associated secretion …

Objective Recently, our laboratory identified sensory innervation within head and neck
squamous cell carcinomas (HNSCCs) and subsequently defined a mechanism whereby …

Many cancer patients will develop complex pain syndromes requiring aggressive,
innovative, and comprehensive multimodal pain management strategies. Recently, data …

The etiology of chronic pelvic pain syndromes remains unknown. In a murine urinary tract
infection (UTI) model, lipopolysaccharide of uropathogenic E. coli and its receptor TLR4 are …

Abstract Background Mesenchymal stem cell (MSCs)-derived small Extracellular Vesicles
(sEVs) are considered as a new cell-free therapy for pain caused by nerve injury, but …

Tumor erosion and metastasis can invade surrounding tissues, damage nerves, and
sensitize the peripheral primary receptors, inducing pain, which can potentially worsen the …