p53 is a well-known tumor suppressor and is also involved in processes of organismal aging
and developmental control. A recent exciting development in the p53 field is the discovery of …

Zebrafish models have significantly contributed to our understanding of vertebrate
development and, more recently, human disease. The growing number of genetic tools …

Background The p53 protein is expressed as multiple isoforms that differ in their N-and C-
terminus due to alternative splicing, promoter or codon initiation usage. Δ40p53 lacks the …

The zebrafish has many advantages as a vertebrate model organism and has been
extensively used in the studies of development. Its potential as a model in which to study …

Mutant p53 proteins accumulate to high levels in human tumors and in preneoplastic lesions
in the skin and fallopian tube. However examination of tissues from mice and fish that are …

Background The role of p53 in the prevention of development of embryos damaged by
genotoxic factors is well recognized. However, whether p53 plays an analogous role in …

It is poorly understood how a single protein, p53, can be responsive to so many stress
signals and orchestrates very diverse cell responses to maintain/restore cell/tissue functions …

We have previously reported that the human p53 gene encodes at least nine different p53
isoforms, including Δ133p53α, which can modulate p53 transcriptional activity and …

The p53 tumor-suppressor protein is a critical mediator of cellular growth arrest and the
induction of apoptosis. To identify proteins involved in the modulation of p53 transcriptional …

The recently discovered p53-related genes, p73 and p63, express multiple splice variants
and N-terminally truncated forms initiated from an alternative promoter in intron 3. To date …