An imbalance between the rate of protein synthesis and folding capacity of the endoplasmic
reticulum (ER) results in stress that has been increasingly implicated in pancreatic islet β …

The endoplasmic reticulum is the main intracellular Ca 2+ store for Ca 2+ release during cell
signaling. There are different strategies to avoid ER Ca 2+ depletion. Release channels …

Perturbations in the normal functions of the endoplasmic reticulum (ER) trigger a signaling
network that coordinates adaptive and apoptotic responses. There is accumulating evidence …

Wolcott-Rallison syndrome (WRS) is a rare autosomal-recessive disorder characterized by
the association of permanent neonatal or early-infancy insulin-dependent diabetes, multiple …

The endoplasmic reticulum (ER) is most notable for its central roles in calcium ion storage,
lipid biosynthesis, and protein sorting and processing. By virtue of its extensive membrane …

The endoplasmic reticulum (ER) functions to properly fold and process secreted and
transmembrane proteins. Environmental and genetic factors that disrupt ER function cause …

Extracellular signal‐regulated protein kinases 1 and 2 (ERK1/2) activities are modulated in a
manner that reflects the secretory demand on β cells to integrate long‐and short‐term …

Free fatty acids cause pancreatic β-cell apoptosis and may contribute to β-cell loss in type 2
diabetes via the induction of endoplasmic reticulum stress. Reductions in eukaryotic …

The endoplasmic reticulum (ER) is a central organelle for protein biosynthesis, folding, and
traffic. Perturbations in ER homeostasis create a condition termed ER stress and lead to …

The dominant C96Y mutation of one of the two murine insulin genes, Ins2, causes diabetes
mellitus in 'Akita'mice. Here we established pancreatic islet β cell lines from heterozygous …