A series of novel synthetic peptides, containing a C-terminal β-amino alcohol linked to p-
methoxybenzoic acid via an ester linkage, have been prepared and tested as inhibitors …

A series of 0-(epoxyalky l) tyrosines and a carboxy terminal (epoxyalkyl) tyrosine and-
phenylalanine were synthesized as potential serine protease inhibitors. N-Acetyl derivatives …

Design Our purpose was to evaluate the inhibitory potential of functional groups
incorporated into substrate analogues by testing them ágainst proteases representing …

A series of 2-(sulfonyloxy) and 2-(acyloxy)-1H-isoindole-1, 3 (2H)-diones and analogous 1H-
benz [de] isoquinoline-1, 3 (2H)-diones was prepared, and their potential to inactivate …

IRREVERSIBLE INHIBITIONS OF SERINE PROTEASES BY PEPTIDYL ALLYLIC HALIDE
DERIVATIVES R Page 1 Pergamon Bioorganic & Medicinal Chemistry Letters, Vol. 6, No. 3, pp …

A series of synthetic peptides in which the C‐terminal carboxyl grouping (‐CO2H) of each
has been chemically converted into a variety of ene dione derivatives (‐CO‐CH= CH‐CO‐X; …

If an enzymologist were to list the attributes of an enzyme that would be most useful for the
design of a mechanism-based inhibitor, the presence of an activesite nucleophile with a well …

We describe herein the design and in vitro biochemical evaluation of a novel class of
mechanism-based inhibitors of human leukocyte elastase (HLE) that inactivate the enzyme …

We introduce a new potent inhibitor, N-[2, 2-dimethyl-3-(N-(4-cyanobenzoyl) amino)
nonanoyl]-l-phenylalanine ethyl ester (3), which preferentially inhibits serine proteases …

Phosphonic acid analogs of N-Cbz-alanine and N-Cbz-phenylalanine have been converted
to the ester and amide fluoridates and evaluated as inactivators of elastase (EC 3.4. 21.11) …