Purpose Cell-in-cell structures are created by one living cell entering another homotypic or
heterotypic living cell, which usually leads to the death of the internalized cell, specifically …

Early signaling in camptothecin-treated MCF-7 cells followed an intrinsic pathway, but death
was delayed and late events exhibited few hallmarks of apoptosis. BH3-only proteins, such …

In this issue, Overholtzer et al.(2007) describe a new nonapoptotic cell death pathway
termed" entosis" in mammary epithelial cells that have detached from the extracellular matrix …

Apoptosis, a fundamental process essential for normal tissue homeostasis and
development, is closely associated with the activation of a class of aspartate-specific …

Caspase-8, a well-characterized initiator of apoptosis, has also been found to play non-
apoptotic roles in cells. In this study, we reveal that caspase-8 can induce cell death in a …

Autophagy, the pathway whereby cell components are degraded by lysosomes, is involved
in the cell response to environmental stresses, such as nutrient deprivation, hypoxia or …

Macroautophagy/autophagy inhibition under stress conditions is often associated with
increased cell death. We found that under nutrient limitation, activation of CASP8/caspase-8 …

Entosis is a cell-in-cell formation mechanism that targets viable cells for uptake in epithelial
cell cultures and human tumors. Entotic cells control their own engulfment, by invading into …

The role of autophagy in cell death is under considerable debate. The process of autophagy
has been shown to lead to either cell survival or cell death depending on cell type and …

Cell cannibalism is a unique pathological phenomenon that has been observed at low
frequency in a variety of human tumor samples (< 0.5%), including breast cancer …