The blood–brain barrier (BBB) is a vital boundary between neural tissue and circulating
blood. The BBB's unique and protective features control brain homeostasis as well as ion …

The central nervous system, one of the most delicate microenvironments of the body, is
protected by the blood‐brain barrier (BBB) regulating its homeostasis. BBB is a highly …

The central nervous system (CNS) poses a unique challenge for drug delivery. The blood–
brain barrier significantly hinders the passage of systemically delivered therapeutics and the …

Neurodegenerative diseases (NDs) represent a heterogeneous group of aging-related
disorders featured by progressive impairment of motor and/or cognitive functions, often …

While the role of the blood-brain barrier (BBB) is increasingly recognized in the
(development of treatments targeting neurodegenerative disorders, to date, few strategies …

Nanoparticles enable the delivery of a great variety of drugs including anticancer drugs,
analgesics, anti-Alzheimer's drugs, cardiovascular drugs, protease inhibitors, and several …

The existence of blood–brain barrier (BBB) hampers the effective treatment of central
nervous system (CNS) diseases. Almost all macromolecular drugs and more than 98% of …

Neurodegenerative diseases are common, incurable neurological disorders with high
prevalence, and lead to memory, movement, language, and intelligence impairments …

A rapid increase in incidence of neurodegenerative disorders has been observed with the
aging of the population. Alzheimer's disease (AD) is the most common neurodegenerative …

With an increase in lifespan and changing population demographics, the incidence of
central nervous system (CNS) diseases is expected to increase significantly in the 21st …