Influx of extracellular Ca2+ is implicated in CNS white matter injury. We studied the effects of
clinically used Ca2+ blockers on mouse adoptive‐transfer EAE (AT‐EAE), a model of MS, an …

Multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE), an animal
model of MS, are inflammatory demyelinating diseases of the central nervous system. The …

Multiple sclerosis is characterised by inflammatory neurodegeneration, with axonal injury
and neuronal cell death occurring in parallel to demyelination. Regarding the molecular …

Multiple sclerosis (MS) is a T‐cell mediated autoimmune disease of the CNS, possessing
both immune and neurodegenerative events that lead to disability. Adoptive transfer (AT) of …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system
(CNS) that affects oligodendrocytes and myelin. Loss of myelin leads to progressive axonal …

The experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis was
used in combination with a Cav1. 2 conditional knock-out mouse (Cav1. 2KO) to study the …

Background Lenabasum is a synthetic cannabinoid receptor type‐2 (CB2) agonist able to
exert potent anti‐inflammatory effects, but its role on T cells remains unknown. Objectives …

Multiple sclerosis (MS) is characterized by a compromised blood-brain barrier (BBB)
resulting in central nervous system (CNS) entry of peripheral lymphocytes, including T cells …

Neuropathological changes following demyelination in multiple sclerosis (MS) lead to a
reorganization of axolemmal channels that causes conduction changes including …

Background: Multiple sclerosis (MS) is a lifelong deteriorating disease characterized by
multiple heterogeneous symptoms. Being an autoimmune disease of the central nervous …