T cell infiltration into the CNS is a significant underlying pathogenesis in autoimmune
inflammatory demyelinating diseases. Several lines of evidence suggest that glutamate …

Background Neutrophil influx is an important sign of hyperacute neuroinflammation,
whereas the entry of activated lymphocytes into the brain parenchyma is a hallmark of …

For the treatment of patients with multiple sclerosis there are no regenerative approaches to
enhance remyelination. Mesenchymal stem cells (MSC) have been proposed to exert such …

One of the family of voltage-gated calcium channels (VGCC), the N-type Ca 2+ channel, is
located predominantly in neurons and is associated with a variety of neuronal responses …

Multiple sclerosis (MS) is a is a chronic, debilitating, neuroinflammatory disease that affects
the central nervous system (CNS). MS affects about 2.5 million patients world-wide. MS …

Conventional wisdom is that B lymphocytes are a major driving force behind autoantibody-
dependent autoimmune diseases, such as systemic lupus erythematosus, and the …

We used genetic deletion of β2‐microglobulin to study the influence of CD8+ T cells on
spinal cord demyelination, remyelination, axonal loss and brainstem N‐acetyl aspartate …

B cells are key contributors to chronic autoimmune pathology in multiple sclerosis (MS).
Clonally related B cells exist in the cerebrospinal fluid (CSF), meninges, and CNS …

Multiple sclerosis (MS) is a severe autoimmune disease leading to demyelination, followed
by consequent axonal degeneration, causing sensory, motor, cognitive, and visual …

The established picture of immunological dysfunction in Multiple Sclerosis (MS) posits a
central role for T cells. As a consequence, the development of disease-modifying treatments …