ROR1, CD38, CD25 and CCR4 are all involved in a variety of diseases including cancer,
autoimmune disorders, and may play a role in tissue rejection. These receptors are attractive …

Receptor tyrosine kinase-like orphan receptor 1 (ROR1) expression is a highly specific
tumor associated antigen expressed in multiple hematological malignancies and solid …

ABSTRACT RORγT is a transcription factor that directs the development of Th17
lymphocytes and other IL-17-expressing cells (eg, Tc17 and ILC3 cells). These cells are …

Targeted therapies require cellular protein expression that meets specific requirements that
will maximize effectiveness, minimize off-target toxicities, and provide an opportunity for a …

RORγT is a transcription factor that directs the development of Th17 lymphocytes and other
IL-17-expressing cells (eg, Tc17 and ILC3 cells). These cells are involved in the body's …

Background Immunotherapy with T cells expressing chimeric antigen receptors (CARs)
specific for a tumor cell-surface molecule is effective for CD19+ B cell malignancies. There is …

ABSTRACT RORγt is the key transcription factor controlling the development and function of
CD4+ Th17 and CD8+ Tc17 cells. Across a range of human tumors, about 15% of the CD4+ …

The retinoic acid-related orphan receptor γt (RORγt) is a nuclear receptor transcription factor
that acts as an immune cell master control switch driving the generation and function of Th17 …

Purpose: The adoptive transfer of T cells modified to express a chimeric antigen receptor
(CAR) comprised of an extracellular single-chain antibody (scFV) fragment specific for a …

Targeted cancer therapies have emerged as new treatment options for various cancer types.
Among targets, receptor tyrosine kinases (RTKs) are among the most promising. ROR1 is a …