We have used tryptic digestion to determine whether Ca2+ can regulate cardiac ryanodine
receptor (RyR) channel gating from within the lumen of the sarcoplasmic reticulum (SR) or …

Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca2+ | Journal of
General Physiology | Rockefeller University Press Skip to Main Content Advertisement …

The mechanism of activation of the cardiac calcium release channel/ryanodine receptor
(RyR) by luminal Ca 2+ was investigated in native canine cardiac RyRs incorporated into …

Ca 2+-dependent inhibition of native and isolated ryanodine receptor (RyR) calcium release
channels from sheep heart and rabbit skeletal muscle was investigated using the lipid …

The synergic effect of luminal Ca2+, cytosolic Ca2+, and cytosolic adenosine triphosphate
(ATP) on activation of cardiac ryanodine receptor (RYR2) channels was examined in planar …

During physical exercise and stress, the sympathetic system stimulates cardiac contractility
via β-adrenergic receptor activation, resulting in protein kinase A (PKA)-mediated …

Aims A domain peptide (DP) matching the Gly2460–Pro2495 region of the cardiac type-2
ryanodine receptor (RyR2), DPc10, is known to mimic channel dysfunction associated with …

Activation of the cardiac ryanodine receptor (RyR2) by Ca2+ is an essential step in
excitation-contraction coupling in heart muscle. However, little is known about the molecular …

The cardiac ryanodine receptor (RyR) is the sarcoplasmic reticulum (SR) Ca-release
channel which is centrally involved in the myocyte excitation–contraction (E–C) coupling …

Cardiac contraction is initiated by Ca2+ leaving the sarcoplasmic reticulum through the
ryanodine receptor (RyR). Although opening of the RyR can be modified by various ligands …