Cholesterol and hematopoietic stem cells: inflammatory mediators of atherosclerosis
Atherosclerosis causing heart attack and stroke is the leading cause of death in the modern
world. Therapy for end-stage atherosclerotic disease using CD34+ hematopoietic cells has …
world. Therapy for end-stage atherosclerotic disease using CD34+ hematopoietic cells has …
Hypercholesterolemia links hematopoiesis with atherosclerosis
O Soehnlein, FK Swirski - Trends in Endocrinology & Metabolism, 2013 - cell.com
Atherosclerosis is characterized by the progressive accumulation of lipids and leukocytes in
the arterial wall. Leukocytes such as macrophages accumulate oxidized lipoproteins in the …
the arterial wall. Leukocytes such as macrophages accumulate oxidized lipoproteins in the …
Hypercholesterolemia‐induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis
T Seijkens, MA Hoeksema, L Beckers… - The FASEB …, 2014 - Wiley Online Library
Modulation of hematopoietic stem and progenitor cells (HSPCs) determines immune cell
function. In this study, we investigated how hypercholesterolemia affects HSPC biology and …
function. In this study, we investigated how hypercholesterolemia affects HSPC biology and …
Hypercholesterolemia tunes hematopoietic stem/progenitor cells for inflammation and atherosclerosis
X Ma, Y Feng - International Journal of Molecular Sciences, 2016 - mdpi.com
As the pathological basis of cardiovascular disease (CVD), atherosclerosis is featured as a
chronic inflammation. Hypercholesterolemia is an independent risk factor for CVD …
chronic inflammation. Hypercholesterolemia is an independent risk factor for CVD …
Cholesterol efflux pathways regulate myelopoiesis: a potential link to altered macrophage function in atherosclerosis
Atherosclerotic cardiovascular disease is a chronic inflammatory disease of the blood
vessels that can lead to myocardial infarction or stroke. The major cell in the atherosclerotic …
vessels that can lead to myocardial infarction or stroke. The major cell in the atherosclerotic …
Lineage of bone marrow–derived cells in atherosclerosis
Atherosclerosis is a chronic inflammatory disease driven by lipids and other atherogenic
factors. It is characterized by a dynamic and complex pathological process of bone marrow …
factors. It is characterized by a dynamic and complex pathological process of bone marrow …
LDL cholesterol modulates human CD34+ HSPCs through effects on proliferation and the IL-17 G-CSF axis
Background Hypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim
Lineage-hematopoietic stem/progenitor cells (HSPCs) give rise to the inflammatory cells …
Lineage-hematopoietic stem/progenitor cells (HSPCs) give rise to the inflammatory cells …
Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways
M Westerterp, S Gourion-Arsiquaud, AJ Murphy, A Shih… - Cell stem cell, 2012 - cell.com
Intact cholesterol homeostasis helps to maintain hematopoietic stem and multipotential
progenitor cell (HSPC) quiescence. Mice with defects in cholesterol efflux pathways due to …
progenitor cell (HSPC) quiescence. Mice with defects in cholesterol efflux pathways due to …
Loss of bone marrow-derived vascular progenitor cells leads to inflammation and atherosclerosis
PJ Goldschmidt-Clermont - American heart journal, 2003 - Elsevier
BACKGROUND: Aging represents the most powerful risk for the development of
atherosclerosis and atherosclerotic thromboembolic complications. Yet, the mechanism by …
atherosclerosis and atherosclerotic thromboembolic complications. Yet, the mechanism by …
The role of monocytosis and neutrophilia in atherosclerosis
DA Chistiakov, AV Grechko… - Journal of cellular …, 2018 - Wiley Online Library
Monocytosis and neutrophilia are frequent events in atherosclerosis. These phenomena
arise from the increased proliferation of hematopoietic stem and multipotential progenitor …
arise from the increased proliferation of hematopoietic stem and multipotential progenitor …