Increased reactive oxygen species (ROS) contributes to the development of endothelial
dysfunction, which is involved in coronary artery spasm (CAS). Xanthine oxidoreductase …

Xanthine oxidoreductase (XOR) is the rate-limiting enzyme in uric acid (UA) production that
plays a pivotal role in generating oxidative stress. Gender differences in the impact of …

Xanthine oxidoreductase (XOR) is a rate-limiting enzyme in the formation of uric acid (UA)
and is involved in the generation of reactive oxygen species (ROS). Overproduction of ROS …

Background and purpose Xanthine oxidoreductase (XOR), which catalyzes purine
catabolism, has two interconvertible forms, xanthine dehydrogenase and xanthine oxidase …

Objective—Xanthine oxidase (XO), a major source of superoxide, has been implicated in
endothelial dysfunction in atherosclerosis. Mechanisms, however, leading to endothelial XO …

Background: The mechanisms of the increased plasma xanthine oxidoreductase (XOR)
activity in outpatients with cardiovascular disease were unclear. Methods and Results: A …

Aims Xanthine oxidoreductase (XOR) is an enzyme regulating uric acid synthesis and
generation of reactive oxygen species. Several studies suggested relationship between …

Xanthine oxidoreductase (XOR) catalyzes the oxidation of hypoxanthine to xanthine, and of
xanthine to uric acid. XOR also enhances the production of reactive oxygen species and …

Background Oxidative stress due to purine degradation is associated with the development
of chronic heart failure (CHF). Xanthine oxidoreductase (XOR) is a rate-limiting enzyme of …

Background Xanthine oxidoreductase (XOR) inhibitor administration, known to reduce uric
acid and reactive oxygen species (ROS) production, also improves vascular endothelial …