Peptide-based PROTAC degrader of FOXM1 suppresses cancer and decreases GLUT1 and PD-L1 expression
K Wang, X Dai, A Yu, C Feng, K Liu… - Journal of Experimental & …, 2022 - Springer
Background Peptide proteolysis-targeting chimeras (p-PROTACs) with advantages of high
specificity and low toxicity have emerged as a powerful technology of targeted protein …
specificity and low toxicity have emerged as a powerful technology of targeted protein …
Novel FOXM1 inhibitor identified via gene network analysis induces autophagic FOXM1 degradation to overcome chemoresistance of human cancer cells
MS Chesnokov, M Halasi, S Borhani, Z Arbieva… - Cell Death & …, 2021 - nature.com
FOXM1 transcription factor is an oncogene and a master regulator of chemoresistance in
multiple cancers. Pharmacological inhibition of FOXM1 is a promising approach but has …
multiple cancers. Pharmacological inhibition of FOXM1 is a promising approach but has …
FoxP3 inhibits proliferation and induces apoptosis of gastric cancer cells by activating the apoptotic signaling pathway
GF Ma, SY Chen, ZR Sun, Q Miao, YM Liu… - Biochemical and …, 2013 - Elsevier
Forkhead Box Protein 3 (FoxP3) was identified as a key transcription factor to the occurring
and function of the regulatory T cells (Tregs). However, limited evidence indicated its …
and function of the regulatory T cells (Tregs). However, limited evidence indicated its …
Knockdown of FoxM1 by siRNA interference decreases cell proliferation, induces cell cycle arrest and inhibits cell invasion in MHCC-97H cells in vitro
Q Wu, C Liu, M Tai, D Liu, L Lei, R Wang… - Acta Pharmacologica …, 2010 - nature.com
Aim: To investigate the effects of small interfering RNA (siRNA) knockdown of forkhead box
M1 (FoxM1) on the proliferation and invasion capacities of human hepatocellular carcinoma …
M1 (FoxM1) on the proliferation and invasion capacities of human hepatocellular carcinoma …
FOXP3 controls an miR-146/NF-κB negative feedback loop that inhibits apoptosis in breast cancer cells
FOXP3 functions not only as the master regulator in regulatory T cells, but also as an X-
linked tumor suppressor. The tumor-suppressive activity of FOXP3 has been observed in …
linked tumor suppressor. The tumor-suppressive activity of FOXP3 has been observed in …
FOXM1 plays a role in autophagy by transcriptionally regulating Beclin-1 and LC3 genes in human triple-negative breast cancer cells
Z Hamurcu, N Delibaşı, U Nalbantoglu… - Journal of Molecular …, 2019 - Springer
Triple-negative breast cancer (TNBC) is associated with poor prognosis owing to its
aggressive and heterogeneous nature, and the lack of therapeutic targets. Although …
aggressive and heterogeneous nature, and the lack of therapeutic targets. Although …
Small-molecule inhibitors targeting FOXM1: current challenges and future perspectives in cancer treatments
S Raghuwanshi, AL Gartel - Biochimica et Biophysica Acta (BBA)-Reviews …, 2023 - Elsevier
Forkhead box (FOX) protein M1 (FOXM1) is a critical proliferation-associated transcription
factor (TF) that is aberrantly overexpressed in the majority of human cancers and has also …
factor (TF) that is aberrantly overexpressed in the majority of human cancers and has also …
FOXD1 facilitates pancreatic cancer cell proliferation, invasion, and metastasis by regulating GLUT1-mediated aerobic glycolysis
K Cai, S Chen, C Zhu, L Li, C Yu, Z He, C Sun - Cell Death & Disease, 2022 - nature.com
Although FOXD1 has been found to be involved in the malignant processes of several types
of cancers, its role in pancreatic cancer (PC) is not well understood. This study aimed to …
of cancers, its role in pancreatic cancer (PC) is not well understood. This study aimed to …
The transcription factor FOXO4 is down-regulated and inhibits tumor proliferation and metastasis in gastric cancer
L Su, X Liu, N Chai, L Lv, R Wang, X Li, Y Nie, Y Shi… - BMC cancer, 2014 - Springer
Background FOXO4, a member of the FOXO family of transcription factors, is currently the
focus of intense study. Its role and function in gastric cancer have not been fully elucidated …
focus of intense study. Its role and function in gastric cancer have not been fully elucidated …
[HTML][HTML] FOXD3 is a tumor suppressor of colon cancer by inhibiting EGFR-Ras-Raf-MEK-ERK signal pathway
K Li, Q Guo, J Yang, H Chen, K Hu, J Zhao, S Zheng… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract Forkhead box D3 (FOXD3), as a transcriptional repressor, is well known to be
involved in the regulation of development. Although FoxD3 is associated with several …
involved in the regulation of development. Although FoxD3 is associated with several …