Phenotypic heterogeneity in neural tube defects: a clue to causal heterogeneity

RA Martin, RM Fineman, LB Jorde… - American Journal of …, 1983 - Wiley Online Library
We report here retrospective data on 991 liveborn and stillborn infants with neural tube
defects (NTDs) born to Utah residents from January 1, 1940 to December 31, 1979. Data …

Etiologic heterogeneity of neural tube defects. II. Clues from family studies.

MJ Khoury, JD Erickson, LM James - American Journal of Human …, 1982 - ncbi.nlm.nih.gov
We previously reported that among neural tube defects (NTDs) with no known causes the
ones that occur alone (singles) have different epidemiologic characteristics from those that …

Studies in neural tube defects I. Epidemiologic and etiologic aspects

NC Myrianthopoulos, M Melnick… - American journal of …, 1987 - Wiley Online Library
Abstract In the NIH Collaborative Perinatal Project, a prospective study of over 53,000
pregnant women and their offspring, 71 single‐born children (13.33/10,000) were found to …

Genetic heterogeneity in neural tube defects.

JL Simpson, J Mills, GG Rhoads… - Annales de …, 1991 - europepmc.org
In 1985-1987, the authors attempted to ascertain all cases of confirmed neural tube defects
(NTD) in California and Illinois, not only among live-born infants (postnatal) but also cases …

Etiologic heterogeneity of neural tube defects: clues from epidemiology

MJ KHOURY, JD ERICKSON… - American Journal of …, 1982 - academic.oup.com
The epidemiology of neural tube defects was reviewed, using data from two birth defects
surveiliance systems: the nationwide Birth Defects Monitoring Program and the Metropolitan …

Occurrence of neural tube defects among first‐, second‐, and third‐degree relatives of probands: Results of a United States study

HV Toriello, JV Higgins, JM Opitz - American Journal of Medical …, 1983 - Wiley Online Library
Data on the occurrence of neural tube defects in first‐, second‐, and third‐degree relatives
of probands were collected in a United States study. The proportions of affected individuals …

Neural tube defects: are neurulation and canalization forms causally distinct?

MJ Seller - American journal of medical genetics, 1990 - Wiley Online Library
Neural tube defects (NTD) may be separated according to the overall location and probable
embryological origin into 2 groups: upper or neurulation defects, and lower or canalization …

Neural tube defects among twin births.

GC Windham, LE Sever - American Journal of Human Genetics, 1982 - ncbi.nlm.nih.gov
To obtain accurate, unbiased rates of neural tube defects (NTDs) in twins, we conducted a
population-based study that included live births and fetal deaths in Los Angeles County …

Neural tube defects: heterogeneity and homogeneity

MJ Seller, DK Kalousek, JM Opitz… - American Journal of …, 1986 - Wiley Online Library
Detailed investigations were made on 150 fetuses with neural tube defects (NTD). After
eliminating those with recognised causes, the rest were found to consist of fetuses with both …

An epidemiologic study of neural tube defects in Los Angeles County II. Etiologic factors in an area with low prevalence at birth

LE Sever - Teratology, 1982 - Wiley Online Library
Epidemiologic characteristics of neural tube defect (NTD) births occurring in Los Angeles
County, California, residents during the period 1966–1972 are presented. The prevalence at …