Tissue infarction, involving death of essentially all cells within a part of the brain, is a
common pathology resulting from stroke and an important determinant of the long-term …

Stroke most commonly results from occlusion of a major artery in the brain and typically
leads to the death of all cells within the affected tissue. Mitochondria are centrally involved in …

Stroke is the leading cause of adult disability and mortality in most developing and
developed countries. The current best practices for patients with acute ischemic stroke …

Pyruvate‐supported oxygen uptake was determined as a measure of the functional capacity
of mitochondria obtained from rat brain during unilateral middle cerebral artery occlusion …

Cerebral ischemia results in a poor oxygen supply and cerebral infarction. Reperfusion to
the ischemic area is the best therapeutic approach. Although reperfusion after ischemia has …

Background and Purpose—Mitochondrial swelling is one of the most striking and initial
ultrastructural changes after acute brain ischemia. The purpose of the present study was to …

The developing and the adult brain respond in similar ways to ischemia, but also display
clear differences. For example, the relative contributions of necrosis and apoptosis to …

Ischemia is accompanied by mitochondrial dysfunction, as assessed by measurements of
mitochondrial respiratory activities in vitro. Following brief periods of ischemia, mitochondrial …

Evidence obtained over the past two decades shows that reactive oxygen species (ROS) are
involved in brain lesions, including those due to cerebral ischemia-reperfusion. The …

Mitochondria represent both the main source and target of reactive oxygen and nitrogen
species (RONS). In view of the large energy expenditure made by neurons during …