Nephropathy is a common microvascular complication of diabetes with a genetic component
for disease development. Genetic analyses have implicated multiple chromosomal regions …

Identification of sequence variants robustly associated with predisposition to diabetic kidney
disease (DKD) has the potential to provide insights into the pathophysiological mechanisms …

Diabetic kidney disease (DKD) has been pointed out as a prominent cause of chronic and
end-stage renal disease (ESRD). There is a genetic predisposition to DKD, although …

OBJECTIVE—The purpose of this study was to examine whether known genetic risk factors
for type 1 diabetes (HLA-DRB1,-DQA1, and-DQB1 and insulin locus) play a role in the …

Diabetic kidney disease and other long-term complications are common in diabetes, and
comprise the main cause of co-morbidity and premature mortality in individuals with …

Background Increased urinary albumin excretion rate is the earliest clinical manifestation of
diabetic nephropathy. The development of microalbuminuria in patients with type 1 diabetes …

Background Previously we performed a linkage scan of 638 African American affected
sibling pairs (ASP) with type 2 diabetes (T2D) enriched for end-stage renal disease (ESRD) …

Diabetes is associated with excess morbidity and mortality due to both micro-and
macrovascular complications, as well as a range of non-classical comorbidities. Diabetes …

Diabetes is the leading cause of ESRD. Despite evidence for a substantial heritability of
diabetic kidney disease, efforts to identify genetic susceptibility variants have had limited …

Aims/hypothesis Diabetic nephropathy is a major diabetic complication, and diabetes is the
leading cause of end-stage renal disease (ESRD). Family studies suggest a hereditary …