Background Hyperglycaemia in diabetes mellitus (DM) alters gene expression regulation in
various organs and contributes to long term vascular and renal complications. We aimed to …

Increased glycemic exposure, even below the diagnostic criteria for diabetes mellitus, is
crucial in the pathogenesis of diabetic microvascular complications represented by …

The increasing prevalence of diabetes mellitus has led to a growing number of chronic
complications including diabetic nephropathy (DN). In high prevalence of diabetes mellitus …

Aims/hypothesis Reasons for the sexual disparity in chronic kidney disease (CKD) are
unclear. To provide insight we contextualised these differences within evolutionary biology …

Diabetes is increasing at daunting rates worldwide, and approximately 40% of affected
individuals will develop kidney complications. Diabetic kidney disease (DKD) is the leading …

Background Diabetic kidney disease (DKD) is one of the most common complications of
diabetes, with approximately 30–40% of patients with type 1 diabetes mellitus and 20% of …

Aims/hypothesis Diabetic kidney disease (DKD) is the leading cause of kidney failure and
has a substantial genetic component. Our aim was to identify novel genetic factors and …

Urinary albumin excretion is an early sign of diabetic kidney disease, affecting every third
individual with diabetes. Despite substantial estimated heritability, only variants in the …

Aims/hypothesis Several studies have provided compelling evidence implicating the Notch
signalling pathway in diabetic nephropathy. Co-regulation of Notch signalling pathway …

Background The prevalence of immunoglobulin A nephropathy (IgAN) seems to be higher in
patients with type 1 diabetes mellitus (T1DM) than that in the general population. However …