Purpose Genetic susceptibility is an important pathogenic mechanism in diabetic kidney
disease (DKD). However, the specific gene variant associated with DKD susceptibility …

Background/Aims: The purpose of the experiment reported here was to assess the
involvement of high-mobility group box-1 (HMGB1), receptor for advanced glycation end …

We formed the GEnetics of Nephropathy–an International Effort (GENIE) consortium to
examine previously reported genetic associations with diabetic nephropathy (DN) in type 1 …

Genetic susceptibility is considered an important factor for the development and progression
to diabetic nephropathy (DN), and for more than 20 years researchers have tried tounravel …

Diabetic kidney disease (DKD) is the most common etiology of chronic kidney disease
(CKD) in the industrialized world and accounts for much of the excess mortality in patients …

Up to 40% of patients with type 1 and type 2 diabetes will develop diabetic nephropathy
(DN), resulting in chronic kidney disease and potential organ failure. There is evidence for a …

Despiteimprovedclinicalcareinpatientswithd…, diabetic complications remain a major
healthcare burden. The management of cardiovascular risk factors, such as hyperlipidemia …

Objective: Diabetic nephropathy (DN) is a long-term complication of both type 1 and type 2
diabetes. Genetic studies on DN have been of little help so far, since several genetic …

BACKGROUND Diabetic kidney disease is one of the common complications of type 2
diabetes (T2D). There are no typical symptoms in the early stage, and the disease will …

Abstract Background and Aim Glutathione peroxidase (GPX) is a class of antioxidant
enzymes that catalyze the reduction of hydrogen peroxide to water. GPX1 is the most …