ROS-responsive polyurethane fibrous patches loaded with methylprednisolone (MP) for restoring structures and functions of infarcted myocardium in vivo

Y Yao, J Ding, Z Wang, H Zhang, J Xie, Y Wang… - Biomaterials, 2020 - Elsevier
Reactive oxygen species (ROS) play an important role in the pathogenesis of numerous
diseases including atherosclerosis, diabetes, inflammation and myocardial infarction (MI). In …

Alleviating oxidative injury of myocardial infarction by a fibrous polyurethane patch with condensed ROS‐scavenging backbone units

J Xie, Y Yao, S Wang, L Fan, J Ding… - Advanced …, 2022 - Wiley Online Library
Excessive reactive oxygen species (ROS) generated after myocardial infarction (MI) result in
the oxidative injury in myocardium. Implantation of antioxidant biomaterials, without the use …

Engineering bioinspired antioxidant materials promoting cardiomyocyte functionality and maturation for tissue engineering application

PA Shiekh, A Singh, A Kumar - ACS applied materials & interfaces, 2018 - ACS Publications
Oxidative stress plays an important role in various pathological conditions, such as wound
healing, inflammation, myocardial infarction, and biocompatibility of the materials …

Multifunctional elastomer cardiac patches for preventing left ventricle remodeling after myocardial infarction in vivo

Y Yao, A Li, S Wang, Y Lu, J Xie, H Zhang, D Zhang… - Biomaterials, 2022 - Elsevier
Myocardial infarction (MI) is still a major cause of mortality and morbidity worldwide.
Elastomer cardiac patches have shown great potential in preventing left ventricle (LV) …

Synthesis, characterization and antioxidant activity of a novel electroactive and biodegradable polyurethane for cardiac tissue engineering application

N Baheiraei, H Yeganeh, J Ai, R Gharibi… - Materials Science and …, 2014 - Elsevier
There has been a growing trend towards applying conducting polymers for electrically
excitable cells to increase electrical signal propagation within the cell-loaded substrates. A …

An elastic, biodegradable cardiac patch induces contractile smooth muscle and improves cardiac remodeling and function in subacute myocardial infarction

KL Fujimoto, K Tobita, WD Merryman, J Guan… - Journal of the American …, 2007 - jacc.org
Objectives: Our objective in this study was to apply an elastic, biodegradable polyester
urethane urea (PEUU) cardiac patch onto subacute infarcts and to examine the resulting …

Bi-layered polyurethane–extracellular matrix cardiac patch improves ischemic ventricular wall remodeling in a rat model

A D'Amore, T Yoshizumi, SK Luketich, MT Wolf, X Gu… - Biomaterials, 2016 - Elsevier
As an intervention to abrogate ischemic cardiomyopathy, the concept of applying a
temporary, local patch to the surface of the recently infarcted ventricle has been explored …

In vivo self-assembled shape-memory polyurethane for minimally invasive delivery and therapy

S Li, H Zhang, J Xie, Z Wang, K Wang, Z Zhai… - Materials …, 2023 - pubs.rsc.org
Advanced elastomers are highly in demand for the fabrication of medical devices for
minimally invasive surgery (MIS). Herein, a shape memory and self-healing polyurethane …

Oxygen releasing and antioxidant breathing cardiac patch delivering exosomes promotes heart repair after myocardial infarction

PA Shiekh, SA Mohammed, S Gupta, A Das… - Chemical Engineering …, 2022 - Elsevier
Constant oxygen supply is inevitable for cardiac tissue function and survival. Myocardial
infarction (MI) leaves heart tissue in a state of oxygen deficiency, causing oxidative stress …

[HTML][HTML] Ameliorating impaired cardiac function in myocardial infarction using exosome-loaded gallic-acid-containing polyurethane scaffolds

A Das, A Nikhil, PA Shiekh, B Yadav, K Jagavelu… - Bioactive Materials, 2024 - Elsevier
Myocardial infarction (MI) can be tackled by implanting cardiac patches which provide
mechanical support to the heart. However, most tissue-engineered scaffolds face difficulty in …