Spheroids are widely used in biology because they provide an in vitro 3-dimensional (3D)
model to study proliferation, cell death, differentiation, and metabolism of cells in tumors and …

Three dimensional multicellular aggregate, also referred to as cell spheroid or microtissue,
is an indispensable tool for in vitro evaluating antitumor activity and drug efficacy. Compared …

There is an increasing interest in using three-dimensional (3D) spheroids for modeling
cancer and tissue biology to accelerate translation research. Development of higher …

The present article highlights the rationale, potential and flexibility of tumor spheroid mono-
and cocultures for implementation into state of the art anti-cancer therapy test platforms …

Three-dimensional in vitro spheroids are a reliable model to study tumor biology and drug
toxicity. However, inconsistencies exist in terms of seeding cell density that governs …

Recently, many types of in vitro 3‐D culture systems have been developed to recapitulate
the in vivo growth conditions of cancer. The cancer 3‐D culture methods aim to preserve the …

Multicellular tumor spheroids are powerful in vitro models to perform preclinical
chemosensitivity assays. We compare different methodologies to generate tumor spheroids …

Improved in vitro models are needed to better understand cancer progression and bridge
the gap between in vitro proof-of-concept studies, in vivo validation, and clinical application …

Introduction: Developing in vitro models for studying cell biology and cell physiology is of
great importance to the fields of biotechnology, cancer research, drug discovery, toxicity …

Multicellular spheroids are three dimensional in vitro microscale tissue analogs. The current
article examines the suitability of spheroids as an in vitro platform for testing drug delivery …