We previously reported the development of a simple, user‐friendly, and versatile 384
hanging drop array plate for 3D spheroid culture and the importance of utilizing 3D cellular …

Tumour spheroid experiments are routinely used to study cancer progression and treatment.
Various and inconsistent experimental designs are used, leading to challenges in …

Introduction: For the past 30 years 2D-cell-based assay models have dominated preclinical
cancer drug discovery efforts. 2D-cell-based models fail to predict in vivo efficacy …

Spheroids are increasingly being employed to answer a wide range of clinical and
biomedical inquiries ranging from pharmacology to disease pathophysiology, with the …

Deciphering the multifactorial determinants of tumor progression requires standardized high-
throughput preparation of 3D in vitro cellular assays. We present a simple microfluidic …

Abstract Three-dimensional (3D) cell culture technology has been steadily studied since the
1990's due to its superior biocompatibility compared to the conventional two-dimensional …

Owing to their in vivo-like characteristics, three-dimensional (3 D) multicellular tumor
spheroid (MCTS) cultures are gaining increasing popularity as an in vitro model of tumors. A …

Although the relevance of three‐dimensional (3‐D) culture has been recognized for years
and exploited at an academic level, its translation to industrial applications has been slow …

Tumors are three-dimensional tissues where close contacts between cancer cells,
intercellular interactions between cancer and stromal cells, adhesion of cancer cells to the …

Tumor spheroid formation in microwell arrays is a promising approach for high-throughput
screening of chemotherapeutic agents. This method offers the advantage of better mimicking …