Background: Drug-induced liver injury (DILI), represented by acetaminophen (APAP), is a
common cause of acute liver failure in clinics. Paeoniflorin (PF) has been proven to …

Confusoside (CF), a major chemical compound in the leaves of Anneslea fragrans Wall., is a
dihydrochalcone glycoside with excellent antioxidant and anti-inflammatory effects …

Acetaminophen (APAP) overdose is very common worldwide and has been widely
recognized as the leading cause of drug-induced liver injury in the Western world. In our …

Background Acetaminophen (paracetamol, APAP) overdose is the principal cause of acute
liver injury (ALI) that leads to liver failure typified with oxidative stress, mitochondrial and …

STRP1, a polysaccharide active ingredient isolated from the traditional Chinese medicine
Sophorae tonkinensis radix, has demonstrated a protective effect against acetaminophen …

Background Oxidative stress-triggered fatal hepatotoxicity is an essential pathogenic factor
in acute liver failure (ALF). Aims To investigate the protective effect of daphnetin (Daph) on …

Summary Acetaminophen (N-acetyl-p-aminophenol, APAP) overdose causes hepatotoxicity,
even liver failure, and oxidative stress plays pivotal role in its pathogenesis. Nicotinic acid …

The vast majority of drug-induced liver injury is mainly attributed to acetaminophen (APAP)
overdose. Salvianolic acid A (Sal A), a powerful water-soluble compound obtained from …

Isorhamnetin is a hepatoprotective flavonoid molecule derived from the leaves and fruits of
Hippophae rhamnoides L. However, the protective effect of isorhamnetin on acetaminophen …

Acetaminophen (APAP)-induced liver injury is one of the most prevalent causes of acute
liver failure (ALF). We assessed the role of the bone morphogenetic protein (BMP) type I …