For the cis and trans stereoisomers of the synthetic anti-microtubule compound tubulozole,
at micromolar concentrations, tubulozole-C is cytotoxic to mammalian cells whereas …

The parasitic protozoan Leishmania mexicana differentiates from a non-motile intracellular
amastigote in the mammalian macrophage phagolysosome into a motile, extracellular …

To aid our investigation of tubulin as an antileishmanial drug target, the effects of the
mammalian antimicrotubule agents ansamitocin P3, taxol, and hemiasterlin on Leishmania …

A new family of antimicrotubule drugs named (3-haloacetamidobenzoyl) ureas and ethyl 3-
haloacetamidobenzoates were found to be cytotoxic to the Leishmania parasite protozoa …

Leishmania microtubules play an important role not only in cell division, but also in keeping
the shape of the parasite and motility of its free-living stages. Microtubules result from the …

Trifluralin, a dinitroaniline microtubule inhibitor currently in use as an herbicide, has been
shown to inhibit the proliferation of Plasmodium falciparum, Trypanosoma brucei, and …

Taxol, a mitotic spindle toxin, was found to selectively inhibit the proliferation of Leishmania
donovani in vitro at nanomolar concentrations with an IC50 of 35 nM. Concentrations of taxol …

Past work suggests that tubulin from kinetoplastid parasites may present an excellent drug
target. To explore this possibility, tubulin was purified on a milligram scale from Leishmania …

Chan et al.(1) state that" in its purified form, trifluralin is generally shown to be
noncarcinogenic, nonteratogenic, and nonmutagenic...." When previous articles by Fong …

Previously, tubulin has been purified from Leishmania amazonensis and used to identify
novel molecules with selective antimitotic activity. However, L. amazonensis is pathogenic …