Treatment of primary herpes simplex virus infection in guinea pigs by imiquimod

RL Miller, LM Imbertson, MJ Reiter, JF Gerster - Antiviral research, 1999 - Elsevier
Imiquimod (also known as R-837 and S-26308) is an imidazoquinoline immune response
modifier and is available in the US and several other countries for the treatment of external …

Posttherapy suppression of genital herpes simplex virus (HSV) recurrences and enhancement of HSV-specific T-cell memory by imiquimod in guinea pigs

CJ Harrison, RL Miller, DI Bernstein - Antimicrobial agents and …, 1994 - Am Soc Microbiol
Imiquimod, an immunomodulator with no direct in vitro antiviral activity, has in vivo anti-
herpesvirus activity by inducing interferon and enhancing other only partially defined …

Immunomodulatory and pharmacologic properties of imiquimod

DN Sauder - Journal of the American Academy of Dermatology, 2000 - Elsevier
Imiquimod, an imidazoquinoline amine, is an immune response modifier recently approved
for the topical treatment of external genital and perianal warts. Although the majority of …

Topical imiquimod: a review of its use in genital warts

CM Perry, HM Lamb - Drugs, 1999 - Springer
Imiquimod is a topically active immunomodulatory agent that is formulated as a 5% cream
for application by the patient. It is the first agent of its class, the immune response modifiers …

Imiquimod.

GA Richwald - Drugs of today (Barcelona, Spain: 1998), 1999 - europepmc.org
The imidazoquinoline, imiquimod, is a low molecular weight, synthetic immune response
modifier that is used for the treatment of external genital and perianal warts. It is formulated …

Daily or weekly therapy with resiquimod (R-848) reduces genital recurrences in herpes simplex virus–infected guinea pigs during and after treatment

DI Bernstein, CJ Harrison, MA Tomai… - The Journal of …, 2001 - academic.oup.com
The effect of resiquimod (R-848), an immune-response modifier that is similar to imiquimod,
on recurrent herpes simplex virus (HSV) was evaluated using the guinea pig model of …

Effect of imiquimod as an adjuvant for immunotherapy of genital HSV in guinea-pigs

DI Bernstein, CJ Harrison, ER Tepe, A Shahwan… - Vaccine, 1995 - Elsevier
Imiquimod, an immunomodulator which upregulates cell-mediated immune responses, was
evaluated as an adjuvant for immunotherapy of recurrent genital herpes simplex virus (HSV) …

Review article imiquimod applied topically: a novel immune response modifier and new class of drug

RL Miller, JF Gerster, ML Owens, HB Slade… - International journal of …, 1999 - Elsevier
Imiquimod (S-26308, R-837)(1-(2-methylpropyl)-1H-imidazo [4, 5-c] quinolin-4 amine), an
immune response modifier, demonstrates potent antiviral and antitumor activity in animal …

Adjuvant effects of imiquimod on a herpes simplex virus type 2 glycoprotein vaccine in guinea pigs

DI Bernstein, RL Miller… - Journal of Infectious …, 1993 - academic.oup.com
The adjuvant effects of imiquimod for a herpes simplex virus (HSV) vaccine were evaluated.
Guinea pigs were immunized with 35 µg oflectin-purified HSV-2 glycoproteins 14 and 35 …

Imiquimod and resiquimod as novel immunomodulators

DH Dockrell, GR Kinghorn - Journal of Antimicrobial …, 2001 - academic.oup.com
Augmenting the host's natural immune response to viruses by the administration of
exogenous cytokines such as interferon-α (IFN-α) is a strategy increasingly employed in …