Aims GPR30 is a novel oestrogen receptor expressed in various tissues, including the heart.
We determined the role of GPR30 in the maintenance of left ventricular (LV) structure and …

The incidence of left ventricular diastolic dysfunction significantly increases in
postmenopausal women suggesting the association between estrogen loss and diastolic …

Abstract G-protein-coupled receptor 30 (GPR30) has been reported to act as a membrane-
bound estrogen receptor that is involved in the mediation of non-genomic estradiol …

G protein-coupled receptor (GPR) 30 is a novel estrogen receptor. Recent studies suggest
that activation of the GPR30 confers rapid cardioprotection in isolated rat heart. It is unknown …

BACKGROUND: Estrogen may protect against the development of cardiovascular disease.
Recently, a receptor known as GPR30 that seems to mediate estrogen's nongenomic effects …

The G-protein coupled estrogen receptor 30 (GPR30) is a seven-transmembrane domain
receptor that mediates rapid estrogen responses in a wide variety of cell types. This receptor …

The mRen2. Lewis congenic strain is an estrogen-sensitive model of hypertension whereby
estrogen depletion produces a significant and sustained increase in blood pressure. The …

Although female protection from cardiovascular diseases declines with the fall in circulating
sex hormones experienced during menopause, clinical trials in older women fail to …

In the present study, we evaluated the transduction pathways involved in the cardiac effects
elicited by 17β-estradiol (E2) on the isolated, Langendorff perfused male Wistar rat heart. E2 …

Aims Estrogen plays an important role in cardioprotection. Animal experiments showed that
the G-protein coupled estrogen receptor 30 (GPR30) specific agonist G1 could reduce post …