Background: Regulatory CD4+ T cells (Tregs) exhibit functional alterations in patients with
multiple sclerosis (MS). Transforming growth factor (TGF)-β is a key regulator of Treg …

Abstract Background Regulatory T cells (Tregs) are functionally defective in patients with
multiple sclerosis (MS) and this dysfunction is related to an imbalanced composition of naïve …

Background: Multiple sclerosis (MS) is an autoimmune disorder that affects the central
nervous system (CNS) through inflammation. MS symptoms become acute if the disease …

Background Accumulating evidence indicates that regulatory T cells (Tregs) play an
important role in the maintenance of immune tolerance. And dysfunction or deficiency of …

Background: Multiple sclerosis (MS) is hypothetically caused by autoreactive Th1 and Th17
cells, whereas Th2 and regulatory T cells may confer protection. The development of Th …

FoxP3+ Treg cells are believed to play a role in the occurrence of autoimmunity and in the
determination of clinical recurrences. Contradictory reports are, however, available …

Background Multiple sclerosis (MS) is an aggressive disease characterized by central
nervous system (CNS) inflammatory and demyelinating lesions. Tolerance failure is …

Regulatory T (Treg) cells are known to suppress excessive inflammation in autoimmune
diseases, including multiple sclerosis (MS). Accumulating evidence suggests that the …

Background Multiple sclerosis (MS), one of the most common diseases of the central
nervous system (CNS), is characterized by demyelination and chronic inflammation of the …

Development of multiple sclerosis (MS) is frequently preceded by an acute or subacute
neurological disturbance referred to as clinically isolated syndrome (CIS). The specific …