The dual roles of autophagy and the GPCRs-mediating autophagy signaling pathway after cerebral ischemic stroke

W Hou, Y Hao, L Sun, Y Zhao, X Zheng, L Song - Molecular Brain, 2022 - Springer
Ischemic stroke, caused by a lack of blood supply in brain tissues, is the third leading cause
of human death and disability worldwide, and usually results in sensory and motor …

The role of oxidative stress and autophagy in atherosclerosis

I Perrotta, S Aquila - Oxidative Medicine and Cellular Longevity, 2015 - Wiley Online Library
Atherosclerosis is a multifactorial, multistep disorder of large‐and medium‐sized arteries
involving, in addition to age, gender and menopausal status, a complex interplay between …

Reactive oxygen species: beyond their reactive behavior

A Tauffenberger, PJ Magistretti - Neurochemical Research, 2021 - Springer
Cellular homeostasis plays a critical role in how an organism will develop and age.
Disruption of this fragile equilibrium is often associated with health degradation and …

[HTML][HTML] Astrocytes autophagy in aging and neurodegenerative disorders

JL Wang, CJ Xu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Astrocytes can serve multiple functions in maintaining cellular homeostasis of the central
nervous system (CNS), and normal functions for autophagy in astrocytes is considered to …

Autophagy in age-associated neurodegeneration

A Metaxakis, C Ploumi, N Tavernarakis - Cells, 2018 - mdpi.com
The elimination of abnormal and dysfunctional cellular constituents is an essential
prerequisite for nerve cells to maintain their homeostasis and proper function. This is mainly …

The role of autophagy in pro‐inflammatory responses of microglia activation via mitochondrial reactive oxygen species in vitro

J Ye, Z Jiang, X Chen, M Liu, J Li… - Journal of …, 2017 - Wiley Online Library
Microglia over‐activation contributes to neurodegenerative processes by neurotoxin factors
and pro‐inflammatory molecules of pro‐inflammatory processes. Mitochondrial reactive …

Altered metabolism in Alzheimer disease brain: role of oxidative stress

NG Rummel, DA Butterfield - Antioxidants & Redox Signaling, 2022 - liebertpub.com
Significance: Alzheimer disease (AD) is an all-too-common condition in the aging
population. However, aging does not automatically equal neurodegeneration and memory …

Oxidative stress‐a direct bridge to central nervous system homeostatic dysfunction and Alzheimer's disease

MM Anwar - Cell biochemistry and function, 2022 - Wiley Online Library
Neurologists have highly observed a frequent increasing number of elderly patients with
Alzheimer's disease (AD) without any relevant evidence of any genetic or known AD‐linked …

Regulation of autophagy in oxygen-dependent cellular stress

SW Ryter, A MK Choi - Current pharmaceutical design, 2013 - ingentaconnect.com
Oxidative stress caused by supraphysiological production of reactive oxygen species (ROS),
can cause cellular injury associated with protein and lipid oxidation, DNA damage, and …

[HTML][HTML] The neuroprotective effects of targeting key factors of neuronal cell death in neurodegenerative diseases: The role of ER stress, oxidative stress, and …

MS Karvandi, F Sheikhzadeh Hesari… - Frontiers in Cellular …, 2023 - frontiersin.org
Neuronal loss is one of the striking causes of various central nervous system disorders,
including major neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's …