Chronic cerebral hypoperfusion (CCH) plays an insidious role in the development of
cognitive impairment. Considerable evidence suggests that Diabetes Mellitus (DM) as a …

Autophagy is an intracellular bulk degradation system that is found ubiquitously in
eukaryotes. Autophagy is responsible for the degradation of most long‐lived proteins and …

With the use of advanced electron microscopy and molecular biology tools, several studies
have shown that autophagy is involved in the development of ischemic stroke. A series of …

Significance: Autophagy, a lysosome-dependent homeostatic process inherent to cells and
tissues, has emerging significance in the pathogenesis of human disease. This process …

Alzheimer's disease (AD) is considered the sixth leading cause of death in elderly patients
and is characterized by progressive neuronal degeneration and impairment in memory …

Autophagy is a degradation pathway for the turnover of dysfunctional organelles or
aggregated proteins in cells. Extensive literature exists supporting a causative role of …

Introduction: Roles of autophagy/mitophagy activation in ischemic stroke remain
controversial. To elucidate potential reasons, we analyze the factors responsible for …

Neurodegenerative diseases affect not only the life quality of aging populations, but also
their life spans. All forms of neurodegenerative diseases have a massive impact on the …

The autophagy-lysosomal pathway is a major proteolytic pathway that in mammalian
systems mainly comprises of macroautophagy and chaperone-mediated autophagy. The …

Oxidative stress and a disturbed cellular protein homeostasis (proteostasis) belong to the
most important hallmarks of aging and of neurodegenerative disorders. The proteasomal …