An indirect immunofluorescence method facilitates detection of thrombospondin type 1 domain–containing 7A–specific antibodies in membranous nephropathy

E Hoxha, LH Beck Jr, T Wiech, NM Tomas… - Journal of the …, 2017 - journals.lww.com
Thrombospondin type 1 domain–containing 7A (THSD7A) is a target antigen identified in
adult membranous nephropathy (MN) along with the major antigen phospholipase A 2 …

Molecular classification of membranous nephropathy

A Pozdzik, F Touzani, I Brochériou… - Current opinion in …, 2019 - journals.lww.com
Summary In 2019, the Kidney Diseases: Improving Global Outcomes guidelines recognized
anti-PLA2R antibodies (but not anti-THSD7A antibodies) as a valuable molecular risk factor …

Relationship between the status of phospholipase A2 receptor and prognosis of idiopathic membranous nephropathy

YQ Li, ZZ Liu, KX Lin, RH Liu, L Ni, GX Liu… - …, 2020 - Wiley Online Library
Aim Serum levels of phospholipase A2 receptor antibody (PLA2R; SAb) and glomerular
deposits of PLA2R antigen (GAg) have been detected in patients with idiopathic …

Strong association of HLA-DR2 and MT1 with idiopathic membranous nephropathy in Japan

Y Hiki, Y Kobayashi, I Itoh, N Kashiwagi - Kidney international, 1984 - Elsevier
Methods Patients. Fifty unrelated Japanese patients with IMN became the subjects of this
study. The diagnosis of IMN was made according to the histological criteria of Ehrenreich …

Approaching biomarkers of membranous nephropathy from a murine model to human disease

CC Wu, JS Chen, CF Huang, CC Chen… - BioMed Research …, 2011 - Wiley Online Library
Background. Membranous glomerulonephropathy (MN) is the most prevalent cause of
nephrotic syndrome in adult humans. However, the specific biomarkers of MN have not been …

Anti–Phospholipase A2 Receptor 1 and Anti–Cysteine Rich antibodies, domain recognition and rituximab efficacy in membranous nephropathy: a prospective cohort …

P Ruggenenti, L Reinhard, B Ruggiero, A Perna… - American Journal of …, 2024 - Elsevier
Rationale & Objective Proteinuria and anti–phospholipase A 2 receptor 1 (anti-PLA 2 R1)
antibody titers are associated with primary membranous nephropathy (MN) outcomes. We …

Hypercholesterolemia correlates with glomerular phospholipase A2 receptor deposit and serum anti-phospholipase A2 receptor antibody and predicts proteinuria …

L Dong, Y Li, S Guo, G Xu, W Wei, M Han - Frontiers in Immunology, 2022 - frontiersin.org
Background The anti-phospholipase A2 receptor (PLA2R) antibody is a non-invasive
diagnostic tool and prognosis predictor of idiopathic membranous nephropathy (IMN) …

Spontaneous remission of proteinuria is a frequent event in phospholipase A2 receptor antibody-negative patients with membranous nephropathy

E Hoxha, S Harendza, HO Pinnschmidt… - Nephrology Dialysis …, 2015 - academic.oup.com
Background Phospholipase A2 receptor antibodies (PLA2R-Ab) and thrombospondin type-1
domain-containing 7A antibodies (THSD7A-Ab) are present in 70–80% of patients with …

Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy

NM Tomas, LH Beck Jr… - … England Journal of …, 2014 - Mass Medical Soc
Background Idiopathic membranous nephropathy is an autoimmune disease. In
approximately 70% of patients, it is associated with autoantibodies against the …

Detection and clinical significance of glomerular M‐type phospholipase A2 receptor in patients with idiopathic membranous nephropathy

H Liu, W Luo, S Gong, X Ding - Internal Medicine Journal, 2016 - Wiley Online Library
Background Glomerular M‐type phospholipase A2 receptor (PLA2R) is important for
diagnosing idiopathic membranous nephropathy (IMN). The relation between glomerular …