Background Uncontrolled bleeding is an important cause of death in trauma victims.
Antifibrinolytic treatment has been shown to reduce blood loss following surgery and may …

Antifibrinolytic drugs for acute traumatic injury - Ker, K - 2015 | Cochrane Library Skip to
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Background Antifibrinolytics reduce death from bleeding in trauma and post-partum
haemorrhage. We examined the effect of treatment delay on the effectiveness of …

Aims: The antifibrinolytic drug tranexamic acid (TXA) improves survival after trauma.
Antifibrinolytic drugs may also improve outcome after spontaneous bleeding, so we …

Improving the outcomes for bleeding trauma patients requires a deeper understanding of the
mechanisms driving hyperfibrinolysis and the subsequent switch toward a prothrombotic …

Activation of the fibrinolytic system is an integral part of vascular haemostatic mechanisms to
maintain vascular patency. The basis of fibrinolysis is the conversion of the inactive …

Objective: To address the clinical and regulatory challenges of optimal primary endpoints for
bleeding patients by developing consensus-based recommendations for primary clinical …

Background Traumatic brain injury (TBI) is a leading cause of death and disability.
Intracranial bleeding is a common complication of TBI, and intracranial bleeding can …

High-quality evidence guiding optimal transfusion and other supportive therapies to reduce
bleeding is needed to improve outcomes for patients with either severe bleeding or …

Objective To develop and validate a prognostic model and a simple model to predict death
due to bleeding in trauma patients. Design Cross-sectional study with multivariable logistic …