From epidemiological data, based on concordance data in family studies, via linkage
analysis to genome-wide association studies, we and others have accumulated robust …

We undertook a meta-analysis of six Crohn's disease genome-wide association studies
(GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up …

Considering epidemiological, genetic and immunological data, we can conclude that the
inflammatory bowel diseases are heterogeneous disorders of multifactorial etiology in which …

Over the course of the past decade, genome‐wide association studies (GWAS) have
revolutionised our understanding of complex disease genetics. One of the diseases that has …

The exact aetiology of Crohn's disease is unknown, though it is clear from early
epidemiological studies that a combination of genetic and environmental risk factors …

Complex disease genetics has been revolutionised in recent years by the advent of genome-
wide association (GWA) studies. The chronic inflammatory bowel diseases (IBDs), Crohn's …

Crohn's disease (CD) is a complex disorder resulting from the interaction of intestinal
microbiota with the host immune system in genetically susceptible individuals. The largest …

Genome-wide association (GWA) studies offer a powerful unbiased method for the
identification of multiple susceptibility genes for complex diseases. Here we report the …

Epidemiological data, detailed molecular studies and recent genome-wide association
studies strongly suggest that ulcerative colitis (UC) and Crohn's disease (CD) are related …

Inflammatory bowel diseases (IBDs) are complex, multifactorial disorders characterized by
chronic relapsing intestinal inflammation. Although etiology remains largely unknown, recent …