Routine use of diuretics and neurohumoral activation make hypokalemia (serum K+< 3. 5
mM) a prevalent electrolyte disorder among heart failure patients, contributing to the …

Hypokalemia is a common biochemical finding in cardiac patients and may represent a side
effect of diuretic therapy or result from endogenous activation of renin–angiotensin system …

Worldwide, approximately three million people suffer sudden cardiac death annually. These
deaths often emerge from a complex interplay of substrates and triggers. Disturbed …

Background—Hypokalemia is known to promote ventricular arrhythmias, especially in
combination with class III antiarrhythmic drugs like dofetilide. Here, we evaluated the …

Key points Hypokalaemia is a risk factor for development of ventricular arrhythmias. In rat
ventricular myocytes, low extracellular K+ (corresponding to clinical moderate …

Potassium (K+) is the most abundant cation in humans and is essential for normal cellular
function. Alterations in K+ regulation can lead to neuromuscular, gastrointestinal, and …

Despite improvements in the therapy of underlying heart disease, sudden cardiac death is a
major cause of death worldwide. Disturbed Na and Ca handling is known to be a major …

Electrolyte disorders can alter cardiac ionic currents kinetics and depending on the changes
can promote proarrhythmic or antiarrhythmic effects. The present report reviews the …

Multilevel inhibition of neurohormonal activation using angiotensin-converting enzyme
inhibitors, β-blockers, angiotensin receptor blockers, and aldosterone antagonists is the …

Background: Cellular repolarization abnormalities occur unpredictably due to disease and
drug effects, and can occur even in cardiomyocytes that exhibit normal action potentials (AP) …