Tissue macrophages are resident phagocytes that acquire specific phenotypes according to
the microenvironment. Morphological and functional heterogeneity has been evidenced in …

The vast majority of macrophages in the body are present in tissues outside the circulation,
yet their remarkable phenotypic heterogeneity within different anatomical compartments in …

Heterogeneity of the macrophage lineage has long been recognized and, in part, is a result
of the specialization of tissue macrophages in particular microenvironments. Circulating …

During development and throughout adult life, macrophages derived from hematopoietic
progenitors are seeded throughout the body, initially in the absence of inflammatory and …

Macrophages are important for tissue development, homeostasis as well as immune
response upon injury or infection. For a long time they were only seen as one uniform group …

Macrophages are dynamic cells that mature under the influence of signals from the local
microenvironment into either classically (M1) or alternatively (M2) activated macrophages …

Macrophages are a diverse phenotype of professional phagocytic cells derived from bone-
marrow precursors and parent monocytes in the peripheral blood. They are essential for the …

Studies on monocyte and macrophage biology and differentiation have revealed the
pleiotropic activities of these cells. Macrophages are tissue sentinels that maintain tissue …

Macrophages are key immune cells in the activation and regulation of immune responses.
These cells are present in all tissues under homeostatic conditions and in many disease …

Macrophages are large mononuclear phagocytes that represent the major differentiated
elements of the mononuclear phagocytic system. They arise from distinct progenitors in the …