In recent years, an increasingly more in depth understanding of tumor metabolism in
tumorigenesis, tumor growth, metastasis, and prognosis has been achieved. The broad …

Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor
metabolism is again in the spotlight of cancer research. Many studies have been carried out …

The early observations by Dr Otto Warburg revealed that fundamentally metabolic
differences exist between malignant tumor cells and adjacent normal cells. Many studies …

About a century ago Otto Warburg observed that tumor cells exhibited increased glycolysis
despite the presence of oxygen and stated this metabolic shift to glycolysis as the origin of …

Macrophages exist in most tissues of the body, where they perform various functions at the
same time equilibrating with other cells to maintain immune responses in numerous …

Cancer metabolism is an essential aspect of tumorigenesis, as cancer cells have increased
energy requirements in comparison to normal cells. Thus, an enhanced metabolism is …

Cancer cells are abnormal cells that can reproduce and regenerate rapidly. They are
characterized by unlimited proliferation, transformation and migration, and can destroy …

Simple Summary Tumors are a complex ecosystem including not only cancer cells, but also
many distinct cell types of the tumor micro-environment. While the Warburg effect assessing …

Awareness that the metabolic phenotype of cells within tumours is heterogeneous—and
distinct from that of their normal counterparts—is growing. In general, tumour cells …

Recent research on cancer metabolism has revealed that individual tumors have highly
heterogeneous metabolic profiles that contribute to the connective metabolic networks within …