• Genetic and environmental influences modulating risk of substance use disorders change
developmentally and across the lifespan.• Genes involved in vulnerability to addictions …

Addictions are a diverse set of common, complex diseases that are to some extent tied
together by shared genetic and environmental etiological factors. They are frequently …

The addictions are common chronic psychiatric diseases that today are prevented and
treated using relatively untargeted and only partially effective methods. The addictions are …

Addictions are serious and common psychiatric disorders, and are among the leading
contributors to preventable death. This selective review outlines and highlights the need for …

Drug addiction is a common brain disorder that is extremely costly to the individual and to
society. Genetics contributes significantly to vulnerability to this disorder, but identification of …

Acamprosate and naltrexone are effective medications in the treatment of alcoholism.
However, effect sizes are modest. Pharmacogenomics may improve patient‐treatment …

Background: Individualized pharmacotherapy requires identification of genetic variants
predictive of treatment response. In OPRM1, Asn40Asp has been reported to be predictive of …

The addictions are multifactorial disorders that are genetically and environmentally
influenced. The family history of addiction is seldom used but can be interpreted to shape …

Background: Pharmacotherapy of alcohol dependence (AD) is at an early stage of
development; currently available medications have limited efficacy. It would be clinically …

Abstract Purpose of Review With the advent of the genome-wide association study (GWAS),
our understanding of the genetics of addiction has made significant strides forward. Here …