Osteoclasts are bone-resorbing cells derived from haematopoietic precursors of the
monocyte-macrophage lineage. Mice lacking Fos (encoding c-Fos) develop osteopetrosis …

Mice lacking the proto-oncogene c-fos develop the bone disease osteopetrosis. Fos mutant
mice were found to have a block in the differentiation of bone-resorbing osteoclasts that was …

Bone formation by osteoblasts is essential for skeletal growth and remodeling. Fra-1 is a c-
Fos-related protein belonging to the AP-1 family of transcription factors. Here we show that …

Osteoclasts are multinucleated haematopoietic cells that resorb bone. Increased osteoclast
activity causes osteoporosis, a disorder resulting in a low bone mass and a high risk of …

Members of the AP-1 family of transcription factors participate in the regulation of bone cell
proliferation and differentiation. We report here a potent AP-1-related regulator of osteoblast …

THE proto-oncogene c-fos is the cellular homologue of v-fos originally isolated from murine
osteosarcoma1. Fos protein is a major component of the AP-1 transcription factor complex …

The activator protein-1 (AP-1) transcription factor complex, in particular the Fos proteins, is
an important regulator of bone homeostasis. Fra-2 (Fosl2), a Fos-related protein of the AP-1 …

Fos plays essential roles in the osteoclastic differentiation of precursor cells generated by
colony-stimulating factor 1 (CSF-1) and receptor activator of NF-κB ligand (RANKL; also …

The transcription factor FOS has long been implicated in the pathogenesis of bone tumours,
following the discovery that the viral homologue, v-fos, caused osteosarcoma in laboratory …

Vertebrate embryologists are beginning to understand the early development decisions that
control the origin and patterning of skeletal elements. However, the regulators governing the …