The discovery of G-quadruplex structures in nucleic acid sequences associated with cancers
has created intense interest in Gquadruplexes as potential drug targets.[1] These …

The G-quadruplex structural motif of DNA has emerged as a novel and exciting target for
anticancer drug discovery. The human telomeric G-quadruplex consists of a single strand …

G-quadruplex ligands are potential anticancer agents as telomerase inhibitors and potential
transcriptional regulators of oncogenes. The search for best-in-class drugs is addressed to …

The rational design of ligands targeting human telomeric DNA G-quadruplexes is a complex
problem due to the structural polymorphism that these sequences can adopt in physiological …

Guanine‐rich sequences of DNA can assemble into tetrastranded structures known as G‐
quadruplexes. It has been suggested that these secondary DNA structures could be …

Although DNA is most widely known for its ability to store and pass along genetic
information, the discovery of G‐quadruplex structures has illuminated a new role for DNA in …

We report in this article the interactions of five N-(1, 10-phenanthrolin-5-yl)-β-
glycopyranosylamine copper (II) complexes with G-quadruplex DNA. Specifically, the …

Guanine-rich nucleic acid sequences are known to form G-quadruplex-four-stranded DNA or
RNA structures stabilized by an array of Hoogsteen hydrogen bonds. G-quadruplex …

DNA is considered an important target for drug design and development. Until recently, the
focus was on double-stranded (duplex) DNA structures. However, it has now been shown …

Telomerase inhibition through guanine quadruplex sequestration by small-molecule drugs
is of great current interest as an anticancer strategy. G-quadruplexes (GQs) can be formed at …