Affinity of anti-spike antibodies to three major SARS-CoV-2 variants in recipients of three major vaccines

PJ Macdonald, JM Schaub, Q Ruan… - Communications …, 2022 - nature.com
Background Measuring anti-viral antibody affinity in blood plasma or serum is a rational
quantitative approach to assess humoral immune response and acquired protection. Three …

Correlation of SARS-CoV-2 viral neutralizing antibody titers with anti-spike antibodies and ACE-2 inhibition among vaccinated individuals

B Grunau, M Prusinkiewicz… - Microbiology …, 2022 - Am Soc Microbiol
ABSTRACT SARS-CoV-2 anti-spike antibody concentrations and angiotensin converting
enzyme-2 (ACE-2) inhibition have been used as surrogates to live viral neutralizing antibody …

Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients

AS Iyer, FK Jones, A Nodoushani, M Kelly… - Science …, 2020 - science.org
We measured plasma and/or serum antibody responses to the receptor-binding domain
(RBD) of the spike (S) protein of SARS-CoV-2 in 343 North American patients infected with …

Affinity of anti-spike antibodies in SARS-CoV-2 patient plasma and its effect on COVID-19 antibody assays

PJ Macdonald, Q Ruan, JL Grieshaber, KM Swift… - …, 2022 - thelancet.com
Background Measuring anti-spike protein antibodies in human plasma or serum is
commonly used to determine prior exposure to SARS-CoV-2 infection and to assess the anti …

Longitudinal Variations in Antibody Responses against SARS-CoV-2 Spike Epitopes upon Serial Vaccinations

D Yalcin, SJ Bennett, J Sheehan, AJ Trauth… - International journal of …, 2023 - mdpi.com
The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) impacted healthcare, the workforce, and worldwide socioeconomics. Multi …

Impaired Humoral Immunity Identified in Inactivated SARS-CoV-2 Vaccine Recipients without Anti-Spike RBD Antibodies

T Sun, Y Wang, X Song, R Li, F Mei, M Yang… - Microbiology …, 2023 - Am Soc Microbiol
Inactivated SARS-CoV-2 vaccines have been deployed in a significant portion of the world
population, who have widely varied responses to vaccination. Understanding this differential …

The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

L Premkumar, B Segovia-Chumbez, R Jadi… - Science …, 2020 - science.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that first emerged in
late 2019 is responsible for a pandemic of severe respiratory illness. People infected with …

Cross-reactivity of antibodies from non-hospitalized COVID-19 positive individuals against the native, B. 1.351, B. 1.617. 2, and P. 1 SARS-CoV-2 spike proteins

M Hojjat Jodaylami, A Djaileb, P Ricard, E Lavallee… - Scientific reports, 2021 - nature.com
SARS-CoV-2 variants of concern (VOCs) have emerged worldwide, with implications on the
spread of the pandemic. Characterizing the cross-reactivity of antibodies against these …

SARS-CoV-2 assays to detect functional antibody responses that block ACE2 recognition in vaccinated animals and infected patients

SN Walker, N Chokkalingam, EL Reuschel… - Journal of Clinical …, 2020 - Am Soc Microbiol
ABSTRACT S evere a cute r espiratory s yndrome co rona v irus 2 (SARS-CoV-2) has
caused a global pandemic of COVID-19, resulting in cases of mild to severe respiratory …

[HTML][HTML] Relationship between anti-spike protein antibody titers and SARS-CoV-2 in vitro virus neutralization in convalescent plasma

E Salazar, SV Kuchipudi, PA Christensen, TN Eagar… - biorxiv, 2020 - ncbi.nlm.nih.gov
Newly emerged pathogens such as SARS-CoV-2 highlight the urgent need for assays that
detect levels of neutralizing antibodies that may be protective. We studied the relationship …