NERD: an umbrella term including heterogeneous subpopulations

E Savarino, P Zentilin, V Savarino - Nature reviews Gastroenterology & …, 2013 - nature.com
Nonerosive reflux disease (NERD) represents the more common phenotypic presentation of
GERD and comprises patients who have typical symptoms without any mucosal breaks at …

Non‐erosive reflux disease (NERD)—acid reflux and symptom patterns

SD Martinez, IB Malagon, HS Garewal… - Alimentary …, 2003 - Wiley Online Library
Background: Recent reports suggest that patients with non‐erosive reflux disease (NERD)
treated with anti‐reflux medications show lower symptom improvement rates than patients …

Non-erosive reflux disease: part of the spectrum of gastro-oesophageal reflux disease, a component of functional dyspepsia, or both?

EM Quigley - European journal of gastroenterology & hepatology, 2001 - europepmc.org
Over the last several decades, the incidences of gastric cancer and peptic ulcer have
declined while the incidences of gastro-oesophageal reflux disease (GORD) and functional …

Distinct clinical characteristics between patients with nonerosive reflux disease and those with reflux esophagitis

JCY Wu, CMY Cheung, VWS Wong… - Clinical Gastroenterology …, 2007 - Elsevier
Background & Aims: It has been postulated that nonerosive reflux disease (NERD) and
erosive reflux disease (ERD) are 2 distinct entities of gastroesophageal reflux disease. The …

Functional heartburn and non-erosive reflux disease

V Savarino, E Savarino, A Parodi, P Dulbecco - Digestive diseases, 2007 - karger.com
Gastroesophageal reflux disease (GERD) is a common disorder in Western countries. For
many years our attention has been focused on patients with erosive esophagitis, but in …

[PDF][PDF] Nonerosive reflux disease (NERD)-an update

T Hershcovici, R Fass - Journal of neurogastroenterology …, 2010 - synapse.koreamed.org
It has been demonstrated that 44% of the US population report gastroesophageal reflux
disease (GERD)-related symptoms at least once a month and 20% once a week. 1, 2 …

Visceral hypersensitivity in non-erosive reflux disease

CH Knowles, Q Aziz - Gut, 2008 - gut.bmj.com
Non-erosive reflux disease (NERD) is defined as the presence of classic symptoms of gastro-
oesophageal reflux disease (GORD) in the absence of oesophageal mucosal injury (or …

Presence of gas in the refluxate enhances reflux perception in non-erosive patients with physiological acid exposure of the oesophagus

S Emerenziani, D Sifrim, FI Habib, M Ribolsi… - Gut, 2008 - gut.bmj.com
Objective: The mechanisms underlying symptoms in gastro-oesophageal reflux disease,
particularly in non-erosive reflux disease (NERD), remain to be fully elucidated. Weakly …

Impedance-pH reflux patterns can differentiate non-erosive reflux disease from functional heartburn patients

E Savarino, P Zentilin, R Tutuian, D Pohl… - Journal of …, 2012 - Springer
Introduction Symptom association is important to distinguish non-erosive reflux disease
[NERD; abnormal oesophageal acid exposure time (AET) and/or positive symptom …

Regional oesophageal sensitivity to acid and weakly acidic reflux in patients with non‐erosive reflux disease

S Emerenziani, M Ribolsi, D Sifrim… - …, 2009 - Wiley Online Library
The mechanisms underlying symptoms in non‐erosive reflux disease (NERD) remain to be
elucidated. Non‐erosive reflux disease patients appear to be more sensitive to intraluminal …