Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models

MJ Bessa, F Brandão, F Rosário, L Moreira… - Journal of Toxicology …, 2023 - Taylor & Francis
Several studies have been conducted to address the potential adverse health risks
attributed to exposure to nanoscale materials. While in vivo studies are fundamental for …

Health effects of inhaled engineered and incidental nanoparticles

AK Madl, KE Pinkerton - Critical reviews in toxicology, 2009 - Taylor & Francis
Engineered nanoscale materials provide tremendous promise for technological
advancements; however, concerns have been raised about whether research of the …

Health effects related to nanoparticle exposures: environmental, health and safety considerations for assessing hazards and risks

DB Warheit, CM Sayes, KL Reed, KA Swain - Pharmacology & therapeutics, 2008 - Elsevier
The field of nanotechnology currently is undergoing a dramatic expansion in material
science research and development. Most of the research efforts have been focused on …

Nanoparticles: a review of particle toxicology following inhalation exposure

S Bakand, A Hayes, F Dechsakulthorn - Inhalation toxicology, 2012 - Taylor & Francis
It is expected that the rapid expansion of nanotechnology will bring many potential benefits.
However, initial investigations have demonstrated that nanomaterials may adversely affect …

[HTML][HTML] Hazard and risk assessment strategies for nanoparticle exposures: how far have we come in the past 10 years?

DB Warheit - F1000Research, 2018 - ncbi.nlm.nih.gov
Nanotechnology is an emerging, cross-disciplinary technology designed to create and
synthesize new materials at the nanoscale (generally defined as a particle size range of≤ …

In vitro human lung cell culture models to study the toxic potential of nanoparticles

F Blank, P Gehr… - … in vitro, in vivo models to …, 2009 - books.google.com
The rapid expansion of nanotechnology has resulted in the production of a variety of
nanoparticles of different sizes, shapes, charge, chemistry, coating and solubility, and the …

A role for nanoparticle surface reactivity in facilitating pulmonary toxicity and development of a base set of hazard assays as a component of nanoparticle risk …

DB Warheit, KL Reed, CM Sayes - Inhalation toxicology, 2009 - Taylor & Francis
Results of some lung toxicology studies in rats indicate that pulmonary exposures to ultrafine
or nanoparticles produce enhanced inflammatory responses compared to fine-sized …

Air-liquid interface exposure to aerosols of poorly soluble nanomaterials induces different biological activation levels compared to exposure to suspensions

T Loret, E Peyret, M Dubreuil… - Particle and Fibre …, 2016 - Springer
Background Recently, much progress has been made to develop more physiologic in vitro
models of the respiratory system and improve in vitro simulation of particle exposure through …

Nanotoxicology: a perspective and discussion of whether or not in vitro testing is a valid alternative

MJD Clift, P Gehr, B Rothen-Rutishauser - Archives of toxicology, 2011 - Springer
Despite the many proposed advantages related to nanotechnology, there are increasing
concerns as to the potential adverse human health and environmental effects that the …

Can in vitro assays substitute for in vivo studies in assessing the pulmonary hazards of fine and nanoscale materials?

CM Sayes, KL Reed, S Subramoney, L Abrams… - Journal of Nanoparticle …, 2009 - Springer
Risk evaluations for nanomaterials require the generation of hazard data as well as
exposure assessments. Most of the validated nanotoxicity studies have been conducted …