Glioblastoma (GB) is the most common and aggressive primary brain malignancy, with poor
prognosis and a lack of effective therapeutic options. Accumulating evidence suggests that …

The Cancer Genome Atlas Project (TCGA) has produced an extensive collection of '-
omic'data on glioblastoma (GBM), resulting in several key insights on expression signatures …

Glioblastoma is one of the first tumors where the biological changes accompanying a single
epigenetic modification, the methylation of the MGMT gene, were found to be of clinical …

Although tumor-propagating cells can be derived from glioblastomas (GBM) of the proneural
and mesenchymal subtypes, a glioma stem-like cell (GSC) of the classic subtype has not …

Glioblastoma (GBM) is highly invasive and the deadliest brain tumor in adults. It is
characterized by inter-tumor and intra-tumor heterogeneity, short patient survival, and lack of …

Glioblastomas,(grade 4 astrocytomas), are aggressive primary brain tumors characterized
by histopathological heterogeneity. High-resolution sequencing technologies have shown …

Gliomas are the most common primary human brain tumors. They comprise a
heterogeneous group of benign and malignant neoplasms that are histologically classified …

Glioblastoma (GBM) is the most aggressive and common form of brain cancer in adults.
GBM is characterized by poor survival and remarkably high tumors heterogeneity (both …

Glioblastoma is classified into two subtypes on the basis of clinical history:“primary
glioblastoma” arising de novo without detectable antecedent disease and “secondary …

Malignant gliomas are central nervous system tumors and remain among the most treatment-
resistant cancers. Exome sequencing has revealed significant heterogeneity and important …