Aims Substance P and neurokinin A (NKA) are sensory nerve neuropeptides encoded by
the TAC1 gene. Substance P is a mast cell secretagogue and mast cells are known to play a …

Background Substance P is a sensory nerve neuropeptide located near coronary vessels in
the heart. Therefore, substance P may be one of the first mediators released in the heart in …

The neuropeptide substance P can induce degranulation of cardiac mast cells at high
concentrations. Herein, we seek to further understand substance P activation of cardiac mast …

Cardiac fibrosis is an underlying cause of diastolic dysfunction, contributing to heart failure.
Substance P (SP) activation of the neurokinin-1 receptor (NK-1R) contributes to cardiac …

The tachykinin, substance P, is found primarily in sensory nerves. In the heart, substance P-
containing nerve fibers are often found surrounding coronary vessels, making them ideally …

Heart failure (HF) is a chronic syndrome in which pathological cardiac remodeling is an
integral part of the disease and mast cell (MC) degranulation-derived mediators have been …

Mast cells have diverse roles throughout the body as evidenced by their heterogeneous
nature. In the heart, cardiac mast cells have been implicated in left ventricular (LV) …

Impairment of myocardial contraction (“myocardial stunning”) occurs during reperfusion after
short ischemic periods. Substance P (SP) is widely distributed in heart and can be released …

Accumulating evidence indicates that substance P is cardioprotective following ischemia-
reperfusion primarily due to its potent coronary vasodilator actions. However, an anti …

Evidence suggests that substance P (SP) participates in the pathology of acute myocardial
ischemia and infarction but the profiles of the peptide in regulation of cardiac functions are …