3. Halpern SD, Randolph AG, Angus DC: No child left behind: Enrolling children and adults
simultaneously in critical care randomized trials. Crit Care Med 2009; 37: 2638–2641 4 …

Objectives: High-quality, adequately powered, randomized controlled trials are needed to
inform the care of critically ill children. Unfortunately, such evidence is not always available …

In their recent editorial [1], Kanthimathinathan and Peters summarize progress made in
paediatric intensive care research during 2018 and report on the number of active paediatric …

The late Professor Brian Kavanagh's “future-gazing” closing plenary lecture at the 2018
World Federation of Pediatric Intensive and Critical Care Societies in Singapore was entitled …

Objectives: Clinical research is a complex scientific and social enterprise. Our objective was
to identify strategies that pediatric critical care trialists consider acceptable, feasible, and …

Conducting clinical trials in pediatric critical care patients are necessary both to determine
the value of new treatment strategies and to improve clinical outcomes. However, there are …

Objectives: Research networks in adult and neonatal critical care have demonstrated
collaborative and successful execution of clinical trials. Such networks appear to have been …

Objective To review the benefits and challenges of using the randomized, controlled trial
(RCT) study design to evaluate preventive and therapeutic interventions in pediatric critical …

The many barriers impeding performance of clinical trials in critically ill children1 have
resulted in a paucity of evidence guiding bedside practice. 2 Children admitted to a …

Abstract Background Intensive Care Medicine set us the task of outlining a global clinical
research agenda for paediatric intensive care (PIC). In line with the clinical focus of this …