Hypoxia and the acquisition of a glycolytic phenotype are intrinsic features of the tumor
microenvironment. The hypoxia inducible factor-1α (HIF-1α) pathway is activated under …

In tumors, rapid cell proliferation associated with deficient vascularization leads to areas of
hypoxia. Tumor hypoxia has direct consequences on clinical and prognostic parameters and …

Hypoxia-inducible factor-1α (HIF-1α) is both a potential endogenous marker of tumor
hypoxia and therapeutic target, and elevated HIF-1α protein levels have been shown to be …

Abstract Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that directly
transactivates genes important for the growth and metabolism of solid tumors. HIF-1α is …

Since the first identification of hypoxic cells in sections of carcinomas in the 1950s, hypoxia
has been known as a central hallmark of cancer cells and their microenvironment. Indeed …

The hypoxia-inducible transcription factors (HIF) 1α and HIF-2α play a critical role in cellular
response to hypoxia. Elevated HIF-α expression correlates with poor patient survival in a …

Decreased aerobic (hypoxic) conditions in tumors induce the release of cytokines that
promote vascularization and thereby enhance tumor growth and metastasis. Recent major …

Neovascularization and increased glycolysis, two universal characteristics of solid tumors,
represent adaptations to a hypoxic microenvironment that are correlated with tumor …

The hypoxia-inducible factor 1 (HIF-1), in addition to genetic and epigenetic changes, is
largely responsible for alterations in cell metabolism in hypoxic tumor cells. This …

Cells exposed to oxygen deprivation in vitro have been shown to reduce proliferation and/or
engage in programmed cell death. There is considerable controversy in the literature as to …