T cells provide critical immune surveillance to the central nervous system (CNS), and the
cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further …

Background Multiple sclerosis (MS), an autoimmune disease of the central nervous system
(CNS), can be suppressed in its early stages but eventually becomes clinically progressive …

The cerebrospinal fluid (CSF) features a unique immune cell composition and is in constant
contact with the brain borders, thus permitting insights into the brain to diagnose and monitor …

Circulating and tissue-resident T cells collaborate in the protection of tissues against harmful
infections and malignant transformation but also can instigate autoimmune reactions. Similar …

Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF
aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains …

T cells within the central nervous system (CNS) have been generally considered
pathogenic, especially in the context of neuroinflammatory disease. However, recent …

Peripheral central nervous system (CNS)–infiltrating lymphocytes are a hallmark of
relapsing-remitting multiple sclerosis. Tissue-resident memory T cells (TRM) not only …

The mechanisms underlying the chronicity of autoimmune diseases of the central nervous
system (CNS) are largely unknown. In particular, it is unclear whether tissue-resident …

Myelin-reactive T cells have been identified in patients with multiple sclerosis (MS) and
healthy subjects with comparable frequencies, but the contribution of these autoreactive T …

INTRODUCTION Under homeostasis, the central nervous system (CNS) hosts microglia
(MG) and CNS-associated macrophages (CAMs). During experimental autoimmune …