Transcriptomic and clonal characterization of T cells in the human central nervous system
JL Pappalardo, L Zhang, MK Pecsok, K Perlman… - Science …, 2020 - science.org
T cells provide critical immune surveillance to the central nervous system (CNS), and the
cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further …
cerebrospinal fluid (CSF) is thought to be a main route for their entry. Further …
[HTML][HTML] Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis
Background Multiple sclerosis (MS), an autoimmune disease of the central nervous system
(CNS), can be suppressed in its early stages but eventually becomes clinically progressive …
(CNS), can be suppressed in its early stages but eventually becomes clinically progressive …
[HTML][HTML] High-dimensional investigation of the cerebrospinal fluid to explore and monitor CNS immune responses
The cerebrospinal fluid (CSF) features a unique immune cell composition and is in constant
contact with the brain borders, thus permitting insights into the brain to diagnose and monitor …
contact with the brain borders, thus permitting insights into the brain to diagnose and monitor …
[HTML][HTML] T-cell surveillance of the human brain in health and multiple sclerosis
J Smolders, MM van Luijn, CC Hsiao… - Seminars in …, 2022 - Springer
Circulating and tissue-resident T cells collaborate in the protection of tissues against harmful
infections and malignant transformation but also can instigate autoimmune reactions. Similar …
infections and malignant transformation but also can instigate autoimmune reactions. Similar …
[HTML][HTML] Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis
D Schafflick, CA Xu, M Hartlehnert, M Cole… - Nature …, 2020 - nature.com
Cerebrospinal fluid (CSF) protects the central nervous system (CNS) and analyzing CSF
aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains …
aids the diagnosis of CNS diseases, but our understanding of CSF leukocytes remains …
Understanding the role of T cells in CNS homeostasis
T cells within the central nervous system (CNS) have been generally considered
pathogenic, especially in the context of neuroinflammatory disease. However, recent …
pathogenic, especially in the context of neuroinflammatory disease. However, recent …
A single-cell analysis framework allows for characterization of CSF leukocytes and their tissue of origin in multiple sclerosis
P Ostkamp, M Deffner… - Science translational …, 2022 - science.org
Peripheral central nervous system (CNS)–infiltrating lymphocytes are a hallmark of
relapsing-remitting multiple sclerosis. Tissue-resident memory T cells (TRM) not only …
relapsing-remitting multiple sclerosis. Tissue-resident memory T cells (TRM) not only …
Tissue-resident CD8+ T cells drive compartmentalized and chronic autoimmune damage against CNS neurons
D Frieser, A Pignata, L Khajavi, D Shlesinger… - Science translational …, 2022 - science.org
The mechanisms underlying the chronicity of autoimmune diseases of the central nervous
system (CNS) are largely unknown. In particular, it is unclear whether tissue-resident …
system (CNS) are largely unknown. In particular, it is unclear whether tissue-resident …
Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis
Myelin-reactive T cells have been identified in patients with multiple sclerosis (MS) and
healthy subjects with comparable frequencies, but the contribution of these autoreactive T …
healthy subjects with comparable frequencies, but the contribution of these autoreactive T …
Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation
MJC Jordão, R Sankowski, SM Brendecke, Sagar… - Science, 2019 - science.org
INTRODUCTION Under homeostasis, the central nervous system (CNS) hosts microglia
(MG) and CNS-associated macrophages (CAMs). During experimental autoimmune …
(MG) and CNS-associated macrophages (CAMs). During experimental autoimmune …